Publikationen

Folgende Arbeiten der Studiengruppe wurden bisher publiziert:

• Pleyer L, Leisch M, Kourakli A, Padron E, Maciejewski J P, Cirici B X, et al.
  Outcome of patients with chronic myelomonocytic leukaemia treated with non-curative therapies: a retrospective cohort study
  The Lancet Haematology 2021; Volume 8, Issue 2, 135-148

• Chanias I, Wilk CM, Benz R, Daskalakis M, Stüssi G, Schmidt A, Bacher U, Bonadies N, on behalf of the Swiss MDS Study Group.
  Survey on Recommended Health Care for Adult Patients with Myelodysplastic Syndromes Identifies Areas for Improvement.
  International Journal of Environmental Research and Public Health. 2020; 17(24):9562

• Chanias I, Bonadies N
  Current Standard of Care in Patients with Myelodysplastic Syndromes and Future Perspectives
  healthbook TIMES Onco Hema 2020;(6):10–22

• Kasprzak A, Nachtkamp K, Kondakci M, Schroeder T, Kobbe G, Kündgen A, Kaivers J, Rautenberg C, Haas R, Gattermann N, Bonadies N, Germing U.
  Analysis of the impact of adherence to guidelines and expert advice in patients with myelodysplastic syndromes.
  Ann Hematol. 2020 Nov 7. Epub ahead of print

• Stojkov K, Silzle T, Stussi G, Schwappach D, Bernhard J, Bowen D, Čermák J, Dinmohamed AG, Eeltink C, Eggmann S, Fenaux P, Germing U, Haschke M, Hellstrom-Lindberg E, Heger M, van de Loosdrecht AA, Passweg J, Pfeilstöcker M, Platzbecker U, Malcovati L, de Almeida AM, Mittelman M, Morgenthaler C, Steensma DP, Santini V, Stauder R, Symeonidis A, Schär S, Maddox C, de Witte T, Bohlius J, Bonadies N.
  Guideline-based indicators for adult patients with myelodysplastic syndromes.
  Blood Adv. 2020 Aug 25;4(16):4029-4044

• Engelbrecht L, Götze KS, Schwamborn K, Alpermann T, Bonadies N, Legros M, Flach J, Pabst Th, Banz Y, Bacher U.
  Correlation of cytomorphology and histopathology in the diagnostic process of myeloid malignancies
  Accepted in Hematology and Medical Oncology 2019

• Bonadies N, Bacher V.U.
  What role can next-generation sequencing play in myelodysplastic syndrome care?
  Expert Rev Hematol. 2019 Jun;12(6):379-382

• Affentranger L, Bohlius J, Hallal M, Bonadies N.
  Efficacy of granulocyte colony stimulating factor in combination with erythropoiesis stimulating agents for treatment of anemia in patients with lower risk myelodysplastic syndromes: a systematic review
  Crit Rev Oncol Hematol. 2019 Apr;136:37-47

• Benzarti S, Daskalakis M, Feller A, Bacher VU, Rüfer A, Holbro A, Schmidt A, Benz R, Solenthaler M, Stüssi G, Arndt V, Bonadies N and the NICER Working Group.
  Trends of Incidence and Survival of Patients with Chronic Myelomonocytic Leukemia between 1999 and 2014: A Comparison between Swiss and American Population-based Cancer Registries
  Cancer Epidemiol. 2019 Jan 25;59:51-57

• Kipfer B, Daikeler T, Kuchen S, Hallal M, Andina N, Allam R, Bonadies N.
  Increased Cardiovascular Comorbidities in Patients with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukaemia Presenting with Systemic Inflammatory and Autoimmune Manifestations
  Seminars in Hematol. 2018 Oct;55(4):242-247

• Silzle T, Bonadies N.
  Myelodysplastische Syndrome. WHO-Klassifikation und Einsatz der «Next-Generation»-Sequenzierung
  PPM MEDIC 2018 Mai; 22-27

• Shumilov E, Flach J, Kohlmann A, Banz Y, Bonadies N, Fiedler M, Pabst T, Bacher U.
  Current status and trends in the diagnostics of AML and MDS
  Blood Rev. 2018 Apr 27

• Ouahchi I et al.
  Microarray-based comparative genomic hybridisation reveals additional recurrent aberrations in adult patients evaluated for myelodysplastic syndrome with normal karyotype
  Br J Haematol. 2018 Jan 9

• Bürki et al.
  Coincidence of 5q deletion and the JAK2V617F mutation: report of two patients with overlapping myelodysplastic and myeloproliferative features and review of the literature
  Leuk Lymphoma. 2018 Jan 3:1-5

• Bonadies N, Bacher VU.
  Highlights der Jahresversammlung der American Society of Hematology (ASH) 2017 in Atlanta: Implementierung einer Präzisionsmedizin bei Patienten mit Myelodysplastischen Syndromen und unklaren Zytopenien
  Leading Opinion Hematology/Oncology 1/2018

• Bonadies N.
  Management of Adult Patients with Myelodysplastic Syndromes
  EMJ Hematol. 2017;5[1]:104-112

• Bonadies N. et al.
  Trends of classification, incidence, mortality, and survival of MDS patients in Switzerland between 2001 and 2012
  Cancer Epidemiol 46, 85-92. 2017 Jan 02

aktuelle Projekte

An folgenden Projekten wird noch intensiv gearbeitet:

• WP0: Swiss Survey on Myelodysplastic Syndromes’ Care Identifies Areas for Improvement (I. Chanias, Dr. M. Wilk, Prof. N. Bonadies). published

• WP1: I-CARE for MDS: Impact of Guidelines Adherence on Effectiveness and Safety of Health CARE Provided to MDS Patients (K. Stojkov, Dr. T. Silzle, Prof. N. Bonadies) O1: published, O2-O3: ongoing

  • WP1.1: Retro- und prospektive Analyse von ESA-assoziierten GBIs (M. Arnold, Prof. N. Bonadies)

• WP2: The Role of Innate Immunity in Chronic Myelomonocytic Leukaemia and Myelodysplastic Syndromes (Prof. R. Allam)
  

  • WP2.1: Expression of immunhistochemical markers for inflammasome activity and immune checkpoint inhibitors in MDS (J. Graf, Prof. N. Bonadies) (manuscript in preparation)

• WP3: Exploration of the Influence of Free Plasma Iron Toxicity and Redox-Stress on Immune Subversion and Clonal Progression in Patients with Myelodysplastic Syndromes (Prof. N. Bonadies)

  • WP3.1: Validation of eLPI assay (A. Vella, Prof. N. Bonadies)

• WP4: Investigation of the role of cytomorphology and histopathology for the diagnosis of MDS in the era of modern genetics (Prof. U. Bacher) published
  

• WP5: The Role of Extracellular Vesicles in Myelodysplastic Syndromes (PD Dr. M. Heller) (manuscript in preparation)
  

• WP6: Characterization of Oncospecific Protein Isoforms as Targets for Myelodysplastic Syndromes (Prof. N. Bonadies, Prof. St. Balabanov)

• WP7: Evaluation of the utility of PROs in MDS and MDS/MPN patients (Dr. L. Njue, Prof. N. Bonadies)

  • WP7.1: Analysis of biomarkers for depression and fatigue (Dr. T. N. Rao)

• WP8: Retrospektiver Vergleich von MDS-Patienten jünger und älter als 50 Jahre (Dr. N Andina, Prof. N. Bonadies)

• WP9: Clinical characteristics and outcomes of hypoplastic MDS and AA in the real-world setting (Prof. N. Bonadies, PD Dr. A. Rovo)

• WP10: Transition from CHIP to MDS (I. Chanias, Prof. N. Bonadies)

• WP11: The wolf in the sheeps clothing: LR-MDS with HR features (H. Simeunovic, Prof. N. Bonadies)

• WP 12: Differences of prognostic factors in MDS and MDS/MPN patients undergoing allo HSCT: A retrospective analysis from the EBMT registry (M. Liu, Prof. N. Bonadies)

• WP 13: Retrospektive Analyse der MDS-Kohorte des Universitätsspitals Basel der Jahre 2012 – 2017 (Dr. G. Stehle)

weitere klinische Studien

In der Schweiz wird mit und ohne unserer Beteiligung an mehreren Studien über die MDS geforscht. Bei clinicaltrials.gov findet man eine weitere Übersicht über Studien mit Schweizer Beteiligung.